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[18F]-labeled substance P antagonist receptor quantifier
Pronunciation
Definition 1
A radiolabeled substance being studied in PET imaging of the brain. It is also being studied as a way to find where cancer cells have spread in patients with pancreatic cancer. It binds to cell receptors for substance P, also known as neurokinin-1, which is found on nerve cells and on some types of cancer cells, such as pancreatic cancer cells. [18F]-labeled substance P antagonist receptor quantifier is a type of PET radioligand and a type of radiolabeled neurokinin-1 receptor antagonist. (NCI Dictionary)
Definition 2
A radioconjugate consisting of the positron emitting radioisotope fluorine F 18 conjugated to the substance P antagonist receptor quantifier (SPA-RQ) used in radioimaging. [18F]-labeled substance P antagonist receptor quantifier is an antagonist of the neurokinin 1 (substance P) receptor (NK1R) and can function as a positron emission tomography (PET) imaging agent for detecting NK1R-expressing cells and tissues. NK1Rs are frequently expressed on the plasma membranes of tumor cells from glioblastoma and breast and pancreatic carcinomas. (NCI Thesaurus)