Health / Medical Topics

    Acquired pure red cell aplasia

    Pronunciation

    Definition 1

    A rare disorder in which the bone marrow makes almost no red blood cells. It may be caused by infection or by certain drugs. Patients with this disorder may also have a thymoma (a tumor of the thymus) or an autoimmune condition such as lupus erythematosus or rheumatoid arthritis. (NCI Dictionary)

    Definition 2

    A disease characterized by normocytic, normochromic anemia, low hematocrit, reticulocytopenia and selective erythroid hypoplasia. It can occur as a chronic or acute form; the former is predominantly seen in adults and the latter in children. Pathogenesis involves immune dysfunction with antibodies directed against erythroid precursor cells or erythropoietin, or due to T-cell mediated suppression of erythropoiesis. (NCI Thesaurus)




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