ADAM Type Metalloprotease Domain

ADAMs are transmembrane proteins containing both a disintegrin and a metalloprotease domain. Two thirds of the proteins with an ADAM type metalloprotease domain also contain the zinc protease pattern which locates the active site of these proteases. As they contain an adhesion domain and a protease domain, ADAM proteins potentially have both cell adhesion and protease activities. They play a role in various biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-alpha release and inflammatory response. In ADAMTS proteins, a closely related family of proteases, the metalloprotease and disintegrin domains are flanked by thrombospondin type I (TSP1) repeat. ADAMTS proteins are soluble, extracellular matrix proteases. (From InterPro IPR001590) (NCI Thesaurus)

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