| Library / English Dictionary |
ADAPTOR
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Device that enables something to be used in a way different from that for which it was intended or makes different pieces of apparatus compatible
Synonyms:
adapter; adaptor
Classified under:
Nouns denoting man-made objects
Hypernyms ("adaptor" is a kind of...):
device (an instrumentality invented for a particular purpose)
Derivation:
adapt (make fit for, or change to suit a new purpose)
Context examples:
CD19 functions as an adaptor protein for Src family kinase amplification, crucial for antigen receptor-induced signal transduction.
(CD19 Antigen, NCI Thesaurus)
CD3-zeta (or CD247) is a transmembrane signaling adaptor polypeptide that regulates the assembly of complete TCR complexes and their expression on the cell surface.
(CD19CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes, NCI Thesaurus)
The 632-amino acid adaptor protein contains a PH domain, a SH2 domain, and a C-terminal tyrosine phosphorylation site.
(APS Protein, NCI Thesaurus)
This protein interfaces the B-cell receptor-associated SYK tyrosine kinase with PLC-gamma, the VAV guanine nucleotide exchange factor, and the GRB2 and NCK adaptor proteins.
(B-Cell Linker, NCI Thesaurus)
This protein binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression.
(AMSH Protein, NCI Thesaurus/LocusLink)
A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart.
(BCR Downstream Signaling 1, NCI Thesaurus)
CBL is recruited to the tyrosine kinase insulin receptor by CAP adaptor protein, through a CAP SH3 domain.
(CBL Protein, NCI Thesaurus)
Encoded as ten alternate splicing variant isoforms by human BIN1 Gene, ubiquitously expressed nucleocytoplasmic adaptor protein Bridging Integrator 1 exhibits differential binding to dynamin, synaptojanin (via sh3 domain), alpha-adaptin, endophilin, clathrin, and MYC protein.
(Bridging Integrator 1, NCI Thesaurus)
A genetically-modified, dendritic cell-based (DCs) vaccine in which the autologous cells are transduced with an adenoviral vector expressing the tumor antigen prostate-specific membrane antigen (PSMA) and a fusion protein composed of synthetic ligand inducible adjuvant iMC composed of a drug-inducible costimulatory CD40 receptor (iCD40) and the adaptor protein MyD88, with potential immunomodulating and antineoplastic activities.
(Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201, NCI Thesaurus)
Expressed by human NRBP Gene, ubiquitous 535-aa 60-kDa Nuclear Receptor Binding Protein is a putative adaptor protein containing 2 putative nuclear receptor-binding motifs, a putative binding domain for SH2 domain-containing proteins, a kinase-like domain, a bipartite nuclear localization signal, and 3 PEST sequences.
(Nuclear Receptor Binding Protein, NCI Thesaurus)
