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ADP
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I. (noun)
Sense 1
Meaning:
Data processing by a computer
Synonyms:
ADP; automatic data processing
Classified under:
Nouns denoting natural processes
Hypernyms ("ADP" is a kind of...):
data processing ((computer science) a series of operations on data by a computer in order to retrieve or transform or classify information)
Hyponyms (each of the following is a kind of "ADP"):
EDP; electronic data processing (automatic data processing by electronic means without the use of tabulating cards or punched tapes)
IDP; integrated data processing (automatic data processing in which data acquisition and other stages or processing are integrated into a coherent system)
Sense 2
Meaning:
An ester of adenosine that is converted to ATP for energy storage
Synonyms:
Classified under:
Hypernyms ("ADP" is a kind of...):
base; nucleotide (a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA))
Context examples:
Platelet activation progresses in stages with an early stage that is stimulated by soluble factors like ADP acting through GPCRs and is reversible and later stages with stronger interaction between platelets that may require interaction between Eph kinases and ephrins.
(Platelet Aggregation Pathway, NCI Thesaurus/BIOCARTA)
Anti-EpCAM-Pseudomonas-exotoxin fusion protein binds to Ep-CAM-positive tumor cells, thereby delivering the Pseudomonas exotoxin A moiety specifically; the Pseudomonas exotoxin A moiety then inactivates elongation factor 2 (EF-2) through ADP ribosylation, resulting in inhibition of protein synthesis in target cells.
(Anti-EpCAM Antibody Fragment-Pseudomonas-exotoxin Fusion Protein, NCI Thesaurus)
Encoded by human SLC25A6 Gene (Mitochondrial Carrier Family), 298-aa 33-kDa homodimeric integral membrane protein Adenine Nucleotide Translocator-3 contains 3 Solcar repeats and plays a fundamental role in cellular energy metabolism by catalyzing ADP/ATP exchange across the inner mitochondrial membrane.
(Adenine Nucleotide Translocator-3, NCI Thesaurus)
The most abundant mitochondrial protein, Adenine Nucleotide Translocator (ANT), is a homodimer of 30-kD subunits embedded asymmetrically in the inner mitochondrial membrane that forms a gated pore through which ADP is moved from the matrix to the cytoplasm.
(Adenosine Nucleotide Transporter, NCI Thesaurus)
Expressed in heart, kidney, liver, skeletal muscle by human SLC25A4 Gene (Mitochondrial Carrier Family), 298-aa 33-kDa homodimeric Adenine Nucleotide Translocator-1 is an integral membrane protein embedded asymmetrically in the inner mitochondrial membrane that catalyzes transmembrane exchange of ADP and ATP and determines the rate of ADP/ATP flux between mitochondrion and cytosol.
(Adenine Nucleotide Translocator-1, NCI Thesaurus)
ANT2 facilitates ADP/ATP exchange between the cytosol and mitochondria.
(Adenine Nucleotide Translocator-2, NCI Thesaurus)
In addition to its oncolytic activity, Ad5-yCD/mutTK(SR39)rep-ADP may exhibit radiosensitizing activity.
(Ad5-yCD/mutTK(SR39)rep-ADP, NCI Thesaurus)
Upon intratumoral administration and transduction of Ad5-yCD/mutTK(SR39)rep-ADP into tumor cells and subsequent expression of cytosine deaminase and viral thymidine kinase, administered prodrugs 5-fluorocytosine (5-FC) and ganciclovir are converted into their respective metabolites 5-fluorouracil (5-FU) and ganciclovir-5-monophosphate (ganciclovir-MP); 5-FU is subsequently metabolized to cytotoxic active metabolites 5-fluoroxyuridine monophosphate (F-UMP) and 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP); ganciclovir-TP subsequently is converted by mammalian thymidine kinase to cytotoxic ganciclovir-triphosphate (ganciclovir -TP).
(Ad5-yCD/mutTK(SR39)rep-ADP, NCI Thesaurus)
A second generation, replication-competent adenovirus type 5 containing a yeast cytosine deaminase(yCD)/mutant sr39 herpes simplex virus thymidine kinase fusion (yCD/mutTKsr39) gene and the 11.6 kDa adenovirus death protein (ADP) gene with potential oncolytic activity.
(Ad5-yCD/mutTK(SR39)rep-ADP, NCI Thesaurus)
