Annexin A5 Protein

Encoded by human Annexin A5 Gene, Annexin A5 is a 35 kD 320-amino acid monomeric placental protein similar to PP4-X that contains 4 annexin repeats; some may bind calcium and phospholipid. PP4 and PP4-X (Lipocortin family) are similar to lipocortin I and calpactin I. PP4 is also an Annexin family member, Ca(2+)-dependent phospholipid binding proteins located on the plasma membrane cytosolic face. PP4 forms a voltage-dependent membrane Ca(2+) channel; key amino acids act as selectivity filters and voltage sensors, regulating pore permeability to ions. As an anticoagulant protein, PP4 acts as an indirect inhibitor of the blood coagulation cascade thromboplastin-specific complex. PP4 may bind ATRX. (OMIM, Swiss-Prot, and NCI) (NCI Thesaurus)

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