| Health / Medical Topics |
Anti-CXCR4 Monoclonal Antibody MDX-1338
An orally bioavailable monoclonal antibody against CXC Chemokine Receptor 4 (CXCR4) with potential antineoplastic activity. CXCR4 monoclonal antibody MDX-1338 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and subsequent receptor activation, which may result in decreased tumor cell proliferation and migration. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types. (NCI Thesaurus)
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A unit of anti-factor Xa anticoagulation activity of unfractionated or low molecular weight heparin.
A unit of anti-coagulation factor potency determined using an in vitro clotting assay against the standard for coagulation factor concentrate.
