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ANTIDIABETIC
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A drug used to treat diabetes mellitus
Synonyms:
antidiabetic; antidiabetic drug
Classified under:
Nouns denoting man-made objects
Hypernyms ("antidiabetic" is a kind of...):
medicament; medication; medicinal drug; medicine ((medicine) something that treats or prevents or alleviates the symptoms of disease)
Hyponyms (each of the following is a kind of "antidiabetic"):
glipizide; Glucotrol (an oral antidiabetic drug (trade name Glucotrol) that stimulates the release of insulin from the pancreas)
DiaBeta; glyburide; Micronase (an oral antidiabetic drug (trade names DiaBeta and Micronase) that stimulates the release of insulin from the pancreas)
Glucophage; metformin (an antidiabetic drug (trade name Glucophage) prescribed to treat type II diabetes)
sulfonylurea (antidiabetic consisting of any of several drugs that reduce the level of glucose in the blood; used to treat diabetes mellitus)
Context examples:
The sodium salt form of edaglitazone, an agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic activity.
(Edaglitazone Sodium, NCI Thesaurus)
The sodium salt form of darglitazone, an agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic and anti-inflammatory activities.
(Darglitazone Sodium, NCI Thesaurus)
An agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
(Buformin, NCI Thesaurus)
In addition, biguanide antidiabetics decrease absorption of glucose from the gastrointestinal tract.
(Biguanide Antidiabetic Agent, NCI Thesaurus)
An agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic and anti-inflammatory activities.
(Darglitazone, NCI Thesaurus)
An agent belonging to the glitazone (thiazolidinedione) class of antidiabetic agents with antihyperglycemic activity.
(Ciglitazone, NCI Thesaurus)
The hydrochloride salt form of buformin, an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
(Buformin Hydrochloride, NCI Thesaurus)
These drugs activate PPAR-gamma and repress expression of 11betaHSD-1 in visceral tissue, perhaps accounting in part for the antidiabetic insulin sensitizing properties of these drugs.
(Metabolic Syndrome Pathway, NCI Thesaurus/BIOCARTA)
Meglitinide antidiabetic agents bind to the ATP-sensitive inwardly-rectifier potassium (IKATP) channels on the membranes of pancreatic beta cells in a manner similar to sulfonylureas but at a discrete contact point on the SUR1 subunit.
(Meglitinide Antidiabetic Agent, NCI Thesaurus)
The natural ligand 15-deoxy prostaglandin J2 stimulated PPAR-gamma interaction with SRC-1, TIF2, TRAP220, and p300, while the synthetic PPAR-gamma ligand troglitazone, an antidiabetic thiazolidinedione drug, did not promote these interactions, indicating that other distinct coactivators may mediate the response to PPAR-gamma when it binds this ligand.
(Obesity and Thermogenesis Pathway, NCI Thesaurus/BIOCARTA)
