| Health / Medical Topics |
Aurora B Serine/Threonine Kinase Inhibitor TAK-901
A small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity. Aurora B kinase inhibitor TAK-901 binds to and inhibits the activity of Aurora B, which may result in a decrease in the proliferation of tumor cells that overexpress Aurora B. Aurora B is a positive regulator of mitosis that functions in the attachment of the mitotic spindle to the centromere; the segregation of sister chromatids to each daughter cell; and the separation of daughter cells during cytokinesis. This serine/threonine kinase may be amplified and overexpressed by a variety of cancer cell types. (NCI Thesaurus)
YOU MAY ALSO LIKE
An orally bioavailable synthetic small molecule with potential antiangiogenic and antineoplastic activities. Aurora A kinase/tyrosine kinase inhibitor ENMD-2076 selectively binds to and…
An orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A, with potential antimitotic and antineoplastic activity. Aurora…
Human AURKC wild-type allele is located in the vicinity of 19q13.43 and is approximately 5 kb in length. This allele, which encodes…
This gene is involved in protein phosphorylation and mitosis.
Human AURKB wild-type allele is located in the vicinity of 17p13.1 and is approximately 6 kb in length. This allele, which encodes…
This gene is involved in mitosis and meiosis.
