BAY 56-3722

Definition 1

A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called camptothecins. (NCI Dictionary)

Definition 2

A water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double strand DNA breakage and triggering of apoptosis. The peptide carbohydrate moiety of this agent stabilizes the lactone form of camptothecin in blood. (NCI Thesaurus)

YOU MAY ALSO LIKE

BAY 43-9006

A drug used to treat advanced kidney cancer and a type of liver cancer that cannot be removed by surgery. It is…

BAY 12-9566

An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors.

BAX wt Allele

Human BAX wild-type allele is located within 19q13.3-q13.4 and is approximately 7 kb in length. This allele, which encodes apoptosis regulator BAX…

BAX Gene

This gene is involved in the regulation of apoptosis by binding p53 protein, which accelerates this mechanism of cell death.

Bavituximab

A substance being studied in the treatment of several types of cancer and infections caused by certain viruses. It binds to substances…

Bavencio

A drug used to treat urothelial carcinoma (a type of bladder cancer) that has advanced or spread to other parts of the…