BET Inhibitor CPI-0610

A small molecule inhibitor of the Bromodomain and Extra-Terminal (BET) family of proteins, with potential antineoplastic activity. Upon administration, the BET inhibitor CPI-0610 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of two bromodomains at the N-terminus, the BET proteins (BRD2, BRD3, BRD4 and BRDT) are transcriptional regulators that play an important role during development and cellular growth. (NCI Thesaurus)

YOU MAY ALSO LIKE

BET Bromodomains 2/3/4 Inhibitor OTX015

A synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potential antineoplastic…

Besunide

An aminosulfamoylbenzoic acid-based diuretic.

Besulpamide

A sulfamoylchlorobenzoic acid derivative with diuretic activity. Besulpamide appears to be similar in diuretic activity to that of chlorthalidone, clopamide and…

Best practice

Treatment that is accepted by medical experts as a proper treatment for a certain type of disease and that is widely used…

Best Overall Response

The most clinically favorable response recorded from the start of the study treatment until the end of treatment.

Best Observation Carried Forward Imputation Technique

A data imputation technique which populates missing values with the best-case nonmissing value.