Beta-Thromboglobulin

Encoded by human PPBP Gene (Alpha Chemokine CXC Family), secreted 128-aa 14-kDa (precursor) Pro-Platelet Basic Protein is a platelet-derived growth factor that is processed to PBP and CTAP-III. Upon platelet activation, PBP is proteolytically converted to Beta Thromboglobulin, a homotetramer released when platelets aggregate. Proteolytic removal of PPBP residues 1-9 produces active peptide CTAP-III/LA-PF4, which stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan, as well as formation and secretion of plasminogen activator. CTAP-III is also proteolytically converted to NAP2, a potent chemoattractant and activator of neutrophils. (NCI Thesaurus)

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