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BLOCKING AGENT
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A class of drugs that inhibit (block) some biological process
Synonyms:
blocker; blocking agent
Classified under:
Nouns denoting man-made objects
Hypernyms ("blocking agent" is a kind of...):
medicament; medication; medicinal drug; medicine ((medicine) something that treats or prevents or alleviates the symptoms of disease)
Hyponyms (each of the following is a kind of "blocking agent"):
alpha-adrenergic blocker; alpha-adrenergic blocking agent; alpha-blocker; alpha blocker (any of various drugs that block alpha-adrenergic receptors; used in treating benign prostatic hyperplasia; relaxes the muscles of the prostate and bladder)
beta-adrenergic blocker; beta-adrenergic blocking agent; beta-blocking agent; beta blocker (any of various drugs used in treating hypertension or arrhythmia; decreases force and rate of heart contractions by blocking beta-adrenergic receptors of the autonomic nervous system)
labetalol; labetalol hydrochloride; Normodyne; Trandate (antihypertensive drug (trade names Trandate and Normodyne) that blocks alpha and beta-adrenergic receptors of the sympathetic nervous system (leading to a decrease in blood pressure))
neuromuscular blocking agent (a substance that interferes with the neural transmission between motor neurons and skeletal muscles)
Context examples:
An extended-release capsule formulation containing the phosphate salt of carvedilol, a nonselective beta-adrenergic blocking agent with alpha 1-adrenergic blocking activity.
(Carvedilol Phosphate Extended-Release Capsule, NCI Thesaurus)
Alpha-adrenergic receptors respond to blocking agents such as phenoxybenzamine and phentolamine.
(Alpha Adrenergic Receptor, NCI Thesaurus)
The phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
(Carvedilol phosphate, NCI Thesaurus)
A synthetic quinolinone derivative and nonselective beta-adrenoceptor blocking agent with anti-glaucoma activity.
(Carteolol, NCI Thesaurus)
The tosylate salt form of bretylium, a quaternary ammonium salt and non-selective adrenergic neuronal blocking agent with anti-arrhythmic properties.
(Bretylium Tosylate, NCI Thesaurus)
A synthetic quinolinone derivative, antihypertensive Carteolol Hydrochloride is a nonselective beta-adrenoceptor blocking agent for beta-1 and beta-2 receptors with no membrane-stabilizing activity but moderate intrinsic sympathomimetic effects.
(Carteolol Hydrochloride, NCI Thesaurus)
A synthetic antihypertensive methoxyphenoxy- 2-propanol derivative with no intrinsic sympathomimetic activity, Carvedilol acts as a nonselective beta-adrenoceptor blocking agent (S(-) enantiomer) and as an alpha 1-adrenoceptor blocker (R(+) and S(-) enantiomers).
(Carvedilol, NCI Thesaurus)
As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation.
(Liarozole Fumarate, NCI Thesaurus)
As a retinoic acid metabolism blocking agent, liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation.
(Liarozole, NCI Thesaurus)
Not dependent on kidney function for elimination, it provides clinical advantages over other non-depolarizing, neuromuscular blocking agents.
(Atracurium Besylate, NCI Thesaurus)
