BRAF(V600E) Inhibitor CEP-32496

An orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity. CEP-32496 specifically and selectively inhibits the activity of the mutated form (V600E) of B-raf kinase. This inhibits the activation of the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway and may result in a decrease in the proliferation of tumor cells expressing the mutated B-raf gene. The Raf mutation BRAF V600E, in which valine is substituted for glutamic acid at residue 600, is frequently found in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. (NCI Thesaurus)

YOU MAY ALSO LIKE

BRAF wt Allele

Human BRAF wild-type allele is located within 7q34 and is approximately 190 kb in length. This allele, which encodes B-Raf proto-oncogene serine/threonine-protein…

BRAF V600K Mutation Present

A molecular finding indicating the presence of a BRAF V600K mutation in a tissue sample.

BRAF V600K Mutation Analysis

A molecular diagnostic test performed to determine the presence or absence of a BRAF V600K mutation in a tissue sample.

BRAF V600E Mutation Present

A molecular finding indicating the presence of a BRAF V600E mutation in a tissue sample.

BRAF V600E Mutation Analysis

A molecular diagnostic test performed to determine the presence or absence of a BRAF V600E mutation in a tissue sample.

BRAF V600 Protein Variation

A change in the valine at position 600 of the serine/threonine-protein kinase B-raf protein to another amino acid.