| Health / Medical Topics |
Cadherin
Definition 1
The cadherins are transmembrane glycoproteins involved in calcium dependent specific cell-cell adhesion through homophilic binding. They are crucial for morphogenesis and synapse formation, but also are involved in tumor invasion. The classical cadherins have five homologous extracellular domains and a cytosolic domain which binds through catenin to the cytoskeleton. The extracellular domains are immunoglobulin-like beta-sandwiches comprising usually 7 strands in the two sheets. (NCI Thesaurus)
Definition 2
family of cell surface glycoproteins, first identified in vertebrates, that mediate calcium dependent, homophilic cell adhesion and thereby control tissue morphogenesis. (NIH CRISP Thesaurus)
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