| Health / Medical Topics |
Calcium-Activated Chloride Channel-2
Encoded by human CLCA2 Gene (similar to CLCA1), the 943-amino acid Calcium-Activated Chloride Channel-2 (CLCA Family) is expressed in trachea, lung, and mammary gland and displays outward rectifying anion conductance. Family members differ in tissue distribution. CLCA2 protein contains a large N-terminal extracellular domain containing conserved cysteines, five transmembrane domains, a monobasic proteolytic cleavage consensus site, potential glycosylation sites, and potential PKC phosphorylation sites. Nascent CLCA2 may be cleaved into 86 kD N-terminal, and 34 kD C-terminal, polypeptides associated with the cell surface. CLCA2 may play a role in the pathogenesis of cystic fibrosis and in cancer metastasis to the lung, mediating vascular arrest and colonization. CLCA2 has been implicated as a tumor suppressor for breast cancer. (from SWISS-PROT, OMIM, and NCI) (NCI Thesaurus)
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