Canertinib dihydrochloride

Pronunciation

Definition 1

A substance being studied in the treatment of some types of cancer. Canertinib dihydrochloride blocks the action of proteins called epidermal growth factor receptors, and may cause cancer cells to die. It is a type of tyrosine kinase inhibitor. Also called canertinib and CI-1033. (NCI Dictionary)

Definition 2

The hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents. (NCI Thesaurus)

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