Caspase

Caspases are a family of intracellular cysteine proteinases involved in inflammation and apoptosis. These enzymes appear to be involved in the initial signaling events, as well as the downstream proteolytic cleavages, that result in apoptotic cell death. They are specific for aspartic acid at the P1 position and are divided into two classes based on the lengths of their N-terminal pro-domains. Caspases-1, -2, -4, -5, -8, and -10 have long pro-domains; caspases-3, -6, -7, and -9 have short pro-domains. (from Science 1998. 281:1312 and Br Med Bull 1997. 53:478) (NCI Thesaurus)

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Human CASP9 wild-type allele is located within 1p36.3-p36.1 and is approximately 32 kb in length. This allele, which encodes caspase-9 protein, is…

CASP9 Gene

This gene plays a role in the initiation of the apoptotic cascade.

CASP8*1 Allele

Human CASP8*1 allele is a variant form of the CASP8 gene which is located within 2q33-q34 and is approximately 54 kb in…

CASP8 wt Allele

Human CASP8 wild-type allele is located within 2q33-q34 and is approximately 54 kb in length. This allele, which encodes caspase-8 protein, plays…

CASP8 Gene

This gene is involved in apoptosis, immune cell homeostasis, lymphocyte activation and immunoprotection.

CASP8 and FADD-Like Apoptosis Regulator Isoform 2

CASP8 and FADD-like apoptosis regulator isoform 2 (221 aa, ~25 kDa) is encoded by the human CFLAR gene. This protein is involved…