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Chloroquinoxaline sulfonamide
Pronunciation
Definition 1
A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor. Also called CQS. (NCI Dictionary)
Definition 2
A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity. Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis. This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner. (NCI Thesaurus)
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