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CHROMOSOMAL ABERRATION
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I. (noun)
Sense 1
Meaning:
Any change in the normal structure or number of chromosomes; often results in physical or mental abnormalities
Synonyms:
chromosomal aberration; chromosomal anomaly; chromosonal disorder; chrosomal abnormality
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("chromosomal aberration" is a kind of...):
aberrance; aberrancy; aberration; deviance (a state or condition markedly different from the norm)
Hyponyms (each of the following is a kind of "chromosomal aberration"):
monosomy (chromosomal abnormality consisting of the absence of one chromosome from the normal diploid number)
trisomy (chrosomal abnormality in which there is one more than the normal number of chromosomes in a cell)
sex-linked disorder (any disease or abnormality that is determined by the sex hormones)
Context examples:
The BTG1 gene and the MYC gene are involved in a chromosomal aberration, translocation t(8;12)(q24;q22), which may be associated with B-cell chronic lymphocytic leukemia.
(BTG1 wt Allele, NCI Thesaurus)
A chromosomal aberration t(15;19)(q13;p13.1) involving the gene and the human BRD4 gene is associated with a lethal midline thoracic, head and neck carcinoma.
(C15orf55 wt Allele, NCI Thesaurus)
This chromosomal aberration is associated with acute monoblastic leukemia.
(MLLT10/CLP1 Fusion Gene, NCI Thesaurus)
A fusion gene that results from a complex chromosomal aberration which fuses exon 2 of the CDK6 gene with exon 10 of the MLL gene.
(CDK6/MLL Fusion Gene, NCI Thesaurus)
Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the O6 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA synthesis.
(Laromustine, NCI Thesaurus)
In a large number of studies, 8-Methoxypsoralen in combination with ultraviolet A radiation induced chromosomal aberrations, sister chromatid exchanges, mutation, DNA damage and DNA cross-links in human cells in vitro.
(Methoxsalen With Ultraviolet A Therapy, NCI Thesaurus)
A chromosomal aberration involving this gene and the SLC45A3 gene may be associated with prostate cancer.
(ELK4 wt Allele, NCI Thesaurus)
Karyotype with at least three chromosomal aberrations.
(Complex Karyotype, NCI Thesaurus)
Ethyl methanesulfonate ethylates DNA, thereby damaging DNA and leading to genetic mutations, single-stranded breaks in DNA, and chromosomal aberrations.
(Ethyl Methanesulfonate, NCI Thesaurus)
Chromosomal aberrations leading to rearrangement or elevated expression of the gene are a factor in a variety of leukemias.
(ETS1 wt Allele, NCI Thesaurus)
