| Library / English Dictionary |
COLCHICINE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An analgesic drug derived from the saffron plant and used to treat gout
Classified under:
Nouns denoting man-made objects
Hypernyms ("colchicine" is a kind of...):
analgesic; anodyne; pain pill; painkiller (a medicine used to relieve pain)
Context examples:
A synthetic, colchicine analogue with potential antineoplastic activity.
(Mivobulin, NCI Thesaurus)
The isethionate salt of mivobulin, a synthetic colchicine analogue with potential antineoplastic activity.
(Mivobulin isethionate, NCI Thesaurus)
Pharmaceutical Anti-gout Preparations such as colchicine, allopurinol, probenecid, and sulfinpyrazone contain natural or synthetic agents against gout, a condition characterized by increased uric acid accumulation.
(Anti-gout Preparation, NCI Thesaurus)
Colchicine may also interrupt the cycle of monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response.
(Colchicine, NCI Thesaurus)
The authors concluded that larger studies are needed to determine if colchicine could prevent the development of type 2 diabetes in people with metabolic syndrome.
(Gout treatment may help prevent obesity-related type 2 diabetes, National Institutes of Health)
Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis.
(Colchicine, NCI Thesaurus)
Colchicine suppresses a multi-protein complex called NLRP3, which triggers the inflammation seen in obesity.
(Gout treatment may help prevent obesity-related type 2 diabetes, National Institutes of Health)
The exact mechanism of action by which colchicines exerts its effect has not been completely established.
(Colchicine, NCI Thesaurus)
Those in the colchicine group also scored lower on a blood test of C-reactive protein and other tests that indicate inflammation.
(Gout treatment may help prevent obesity-related type 2 diabetes, National Institutes of Health)
In the current study, researchers led by Jack A. Yanovski, M.D., Ph.D., of NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) randomly assigned 21 study participants to received colchicine twice a day for 3 months, while 19 participants received a placebo.
(Gout treatment may help prevent obesity-related type 2 diabetes, National Institutes of Health)
