| Library / English Dictionary |
CONJUGATED
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Of an organic compound; containing two or more double bonds each separated from the other by a single bond
Synonyms:
conjugate; conjugated
Classified under:
Similar:
bound (held with another element, substance or material in chemical or physical union)
Domain category:
chemical science; chemistry (the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions)
Sense 2
Meaning:
Formed by the union of two compounds
Example:
a conjugated protein
Synonyms:
conjugate; conjugated
Classified under:
Similar:
bound (held with another element, substance or material in chemical or physical union)
Domain category:
chemical science; chemistry (the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions)
Sense 3
Meaning:
Joined together especially in a pair or pairs
Synonyms:
conjugate; conjugated; coupled
Classified under:
Adjectives
Similar:
united (characterized by unity; being or joined into a single entity)
II. (verb)
Sense 1
Past simple / past participle of the verb conjugate
Context examples:
A peptide vaccine, containing human tumor-associated epithelial mucin (MUC1) conjugated with keyhole limpet hemocyanin (KLH), with potential antineoplastic activity.
(MUC1-KLH Conjugate Vaccine, NCI Thesaurus)
When conjugated with a radioactive isotope, Lym-1 monoclonal antibody selectively transports the cytotoxic radioisotope to HLA-Dr10-expressing tumor cells, thereby sparing healthy B-cells and normal tissues.
(Monoclonal Antibody Lym-1, NCI Thesaurus)
This agent may be conjugated with various toxins in order to target their cytotoxic activity to tumor cells expressing the L6 antigen.
(Monoclonal Antibody L6, NCI Thesaurus)
An immunoconjugate consisting of milatuzumab, a humanized monoclonal antibody against CD74, conjugated to the anthracycline antibiotic doxorubicin with potential antineoplastic activity.
(Milatuzumab-Doxorubicin Antibody-Drug Conjugate, NCI Thesaurus)
An orally available formulation containing naloxol, a derivative of the opioid antagonist naloxone, conjugated with polyethylene glycol (PEG), with opioid-induced constipation (OIC)-relieving activity.
(Oral Pegylated Naloxol, NCI Thesaurus)
A recombinant, human monoclonal antibody targeting an extracellular epitope of human prostate specific membrane antigen (PSMA) that is conjugated with a fluorescent dye A488, with potential imaging activity.
(Anti-PSMA Monoclonal Antibody MDX1201-A488, NCI Thesaurus)
An immunoconjugate consisting of a human IgG1 monoclonal antibody directed against CD27L conjugated, via a non-cleavable linker, to the cytotoxic agent maytansinoid DM1, with potential antineoplastic activity.
(Anti-CD27L Antibody-Drug Conjugate AMG 172, NCI Thesaurus)
An immunoconjugate consisting of the humanized monoclonal antibody M9346A against folate receptor 1 (FOLR1) conjugated, via the disulfide-containing cleavable linker sulfo-SPDB, to the cytotoxic maytansinoid DM4, with potential antineoplastic activity.
(Anti-FOLR1-Monoclonal Antibody-Maytansinoid Conjugate IMGN853, NCI Thesaurus)
A complex of polyethylene glycol conjugated with human recombinant cytokine interleukin-2 (IL-2) with antineoplastic activity.
(PEG-interleukin-2, NCI Thesaurus)
An immunoconjugate consisting of an anti-CD19 monoclonal antibody conjugated to the maytansinoid DM4, a derivative of the cytotoxic agent maytansine (DM1), with potential antineoplastic activity.
(Anti-CD19-DM4 Immunoconjugate SAR3419, NCI Thesaurus)
