CTCAE Grade 4 Oral Cavity or Gum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Oral Cavity NOS Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Oral Cavity Mucositis or Stomatitis by Functional or Symptomatic Classification

Symptoms associated with life-threatening consequences

CTCAE Grade 4 Oral Cavity Mucositis or Stomatitis by Clinical Examination Classification

Tissue necrosis; significant spontaneous bleeding; life-threatening consequences

CTCAE Grade 4 Oral Cavity Hemorrhage

Life-threatening consequences; major urgent intervention indicated

CTCAE Grade 4 Oral Cavity GI Fistula

CTCAE Grade 4 Optic Disc Edema

Blindness (20/200 or worse)