CTCAE Grade 4 Rectum Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) (NCI Thesaurus/CTCAE)

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Life-threatening consequences; major urgent intervention indicated

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Life-threatening consequences; major urgent intervention indicated

CTCAE Grade 4 Rash Erythema Multiforme

CTCAE Grade 4 Rash Desquamation

Generalized exfoliative, ulcerative, or bullous dermatitis

CTCAE Grade 4 Radiation Excluding Chemoradiation

Skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site