CTCAE Grade 4 Sinus Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Sinus Bradycardia

Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)

CTCAE Grade 4 Sinus Arrhythmia

Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)

CTCAE Grade 4 Sick Sinus Syndrome

Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)

CTCAE Grade 4 Serum Hypophosphatemia

<1.0 mg/dL <0.3 mmol/L

CTCAE Grade 4 Serum Hyponatremia

<120 mmol/L

CTCAE Grade 4 Serum Hypomagnesemia

<0.7 mg/dL <0.3 mmol/L