CTCAE Grade 4 Vagina Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis) (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Vagina Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

CTCAE Grade 4 Vagina Hemorrhage

Life-threatening consequences; major urgent intervention indicated

CTCAE Grade 4 Vagina Fistula

Life-threatening consequences; operative intervention requiring partial or full organ resection; permanent urinary diversion

CTCAE Grade 4 Uveitis

Blindness (20/200 or worse)

CTCAE Grade 4 Uterus Stricture or Stenosis

Life-threatening consequences; organ failure or operative intervention requiring organ resection indicated

CTCAE Grade 4 Uterus Perforation

Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated