CYP2A6 wt Allele

Human CYP2A6 wild-type allele is located in the vicinity of 19q13.2 and is approximately 7 kb in length. This allele, which encodes cytochrome P450 2A6 protein, plays a role in the hydroxylation of coumarin and oxidation of nicotine. It is also involved in the metabolism of other drugs and xenobiotics. Certain allelic variants of the CYP2A6 gene contribute to the poor metabolizer phenotype. The CYP2A6 wild-type allele is both a determinant of smoking behavior and a susceptibility factor for lung cancer. (NCI Thesaurus)

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CYP2A6 Gene

This gene plays a role in the oxidation of nicotine to its carcinogenic metabolites.

CYP27B1 wt Allele

Human CYP27B1 wild-type allele is located within 12q13.1-q13.3 and is approximately 5 kb in length. This allele, which encodes 25-hydroxyvitamin D-1 alpha…

CYP27B1 Gene

This gene is involved in vitamin D metabolism and calcium homeostasis.

CYP27A1 wt Allele

Human CYP27A1 wild-type allele is located within 2q33-qter and is approximately 34 kb in length. This allele, which encodes sterol 26-hydroxylase, mitochondrial…

CYP27A1 Gene

This gene is involved in cholesterol homeostasis and bile synthesis.

CYP26B1 wt Allele

Human CYP26B1 wild-type allele is located in the vicinity of 2p13.2 and is approximately 19 kb in length. This allele, which encodes…