CYP2D6*1 Allele

Human CYP2D6*1 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*1 protein. There are multiple haplotypes of the CYP2D6*1 allele. The nucleotide sequence of CYP2D6*1A is identical to that of the wild-type allele and exhibits no mutations. Four other haplotypes of the CYP2D6*1 allele exhibit SNPs that have no effect on the enzymatic activity of the corresponding cytochrome P450 2D6*10 proteins. (NCI Thesaurus)

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