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CYSTINE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A crystalline amino acid found in proteins (especially keratin); discovered in bladder stones
Classified under:
Hypernyms ("cystine" is a kind of...):
amino acid; aminoalkanoic acid (organic compounds containing an amino group and a carboxylic acid group)
Context examples:
Upon administration of cysteine-rich whey protein isolate, cystine and glutamylcystine are taken up by cells and release free cysteine.
(Cysteine-Rich Non-Denatured Whey Protein Isolate IMN1207, NCI Thesaurus)
Cystine is abundant in many proteins of skeletal tissues and skin, and found in insulin and digestive enzymes chromotrypsinogen A, papain, and trypsinogen.
(Cystine, NCI Thesaurus)
Expressed in fetal perichondrium, uterus, cytotrophoblasts, and syncytiotrophoblasts as a 139-aa 15-kDa precursor by human INSL4 Gene (Insulin Family), Insulin-Like Peptide 4 contains 6 consensus half-cystine residues essential for tertiary structure.
(Insulin-Like Peptide 4, NCI Thesaurus)
This agent binds to the catalytic domain of EGFR with a 1:1 stoichiometry and inactivates the EGFR tyrosine kinase activity through alkylation of a cystine residue (Cys-773) within the ATP-binding pocket, thereby inhibiting proliferation of EGFR-expressing tumor cells.
(PD-168393, NCI Thesaurus)
Cysteamine bitartrate enters the cell and reacts with cystine producing cysteine and cysteine-cysteamine mixed disulfide compound, both of which, unlike cystine, can pass through the lysosomal membrane.
(Cysteamine Bitartrate, NCI Thesaurus)
Cystine/glutamate transporter protein (501aa, ~55 kDa) is encoded by the human SLC7A11 gene.
(Cystine/Glutamate Transporter Protein, NCI Thesaurus)
It is associated with slight increase of the plasma cystine, cystinuria, aminoaciduria, glycosuria, polyuria, hypophosphatemia, rickets, and renal tubular dysfunction. —2004
(Cystinosis, NCI Thesaurus)
