Death Domain-Associated Protein 6

Encoded by human DAXX Gene (DAXX Family), ubiquitous nuclear/cytoplasmic Death Domain-Associated Protein 6 is a 740-amino acid 81.4-kD sumoylated putative phosphohomomultimer with NLS, Glu-rich, and JNK activation domains. Bound to TGFBR2 and TNFRSF6 FAS death domain via C-terminus, DAXX bridges apoptotic FAS activation with caspase-independent ASK1 activation of JNK. HSPB1/HSP27-DAXX may block TNFRSF6/ASK1. DAXX co-represses transcription by recruitment to nucleoli or PML/POD/ND10 nuclear bodies through interaction with MCSR1 or PML and directly inhibits PAX3 and ETS1. As part of PAX5/CREBBP complex, DAXX may modulate PAX5 activity. DAXX binds to SLC2A4/GLUT4, CENPC1, UBE2I, PAX7, DEK, HDAC1, HDAC2, HDAC3, and histones H2A, H2B, H3, and H4. (from LocusLink, Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)

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