| Health / Medical Topics |
Deltex Homolog 1
Deltex Homolog 1, encoded by the human DTX1 gene, is a transcription corepressor. Notch1 activates CSL by displacing corerepssors and recruiting coactivator. The N terminus of Deltex Homolog 1 directly interacts with the Notch1 ankyrin repeats, and specifically prevents the recruitment of coactivators and limits CSL activation below the threshold needed for induction of T cell fate. Deltex Homolog 1 may also actively promote B cell fate in common lymphoid progenitors. This protein is expressed in T lymphocytes at all stages of development. (From LocusLink, OMIM and NCI) (NCI Thesaurus)
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