Library / English Dictionary

DETOXIFICATION

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

Treatment for poisoning by neutralizing the toxic properties (normally a function of the liver)

Classified under:

Nouns denoting acts or actions

Hypernyms ("detoxification" is a kind of...):

medical aid; medical care (professional treatment for illness or injury)

Derivation:

detoxify (remove poison from)

Sense 2

Meaning:

A treatment for addiction to drugs or alcohol intended to remove the physiological effects of the addictive substances

Classified under:

Nouns denoting acts or actions

Hypernyms ("detoxification" is a kind of...):

intervention; treatment (care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury))

Derivation:

detoxify (treat for alcohol or drug dependence)

Credits

 Context examples: 

Nitrosamine Metabolism involves important cellular biochemical detoxification reactions that chemically modify the N-nitroso derivatives of secondary amines, formed by the combination of nitrates with amines.

(Nitrosamine Metabolism, NCI Thesaurus)

This gene is involved in the detoxification of xenobiotic compounds.

(NNMT Gene, NCI Thesaurus)

They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification.

(Peroxisome Biogenesis Pathway, NCI Thesaurus/KEGG)

In phase II detoxification, liver cells add a substance (such as cysteine, glycine, or a sulfur molecule) to a toxic chemical or drug, to make it less harmful.

(phase II detoxification, NCI Dictionary)

Specifically, this agent has been shown to reactivate gene expression of a detoxification enzyme, glutathione S-transferase that is silenced in prostate carcinoma.

(Phenethyl isothiocyanate, NCI Thesaurus)

Furthermore, this agent has been shown to reactivate the gene expression of certain detoxification enzymes.

(Phenethyl Isothiocyanate-containing Watercress Juice, NCI Thesaurus)

GSSG and GSH together play important roles in numerous redox reactions, such as those involved in the detoxification of harmful substances and free radicals, and in reactions preventing oxidative damage in erythrocytes.

(Oxiglutatione, NCI Thesaurus)

Enzymes involved in the Phase II detoxification of xenobiotics to reduce cellular stress include glutathione transferases, quinone reductase, epoxide hydrolase, heme oxygenase, UDP-glucuronosyl transferases, and gamma-glutamylcysteine synthetase.

(Oxidative Stress Pathway, NCI Thesaurus/BIOCARTA)

This allele, which encodes nicotinamide N-methyltransferase protein, plays a role in the detoxification of metabolism of xenobiotic compounds.

(NNMT wt Allele, NCI Thesaurus)

This allele, which encodes ribosyldihydronicotinamide dehydrogenase [quinone] protein, plays a role in both vitamin metabolism and detoxification.

(NQO2 wt Allele, NCI Thesaurus)