| Health / Medical Topics |
Dihydropyrimidine Dehydrogenase Deficiency
A rare disorder characterized by an inborn error in pyrimidine metabolism. It results in the deficiency or complete absence of the enzyme dihydropyrimidine dehydrogenase. Individuals with this disorder may develop a severe toxicity reaction if they are exposed to the chemotherapeutic agent 5-fluorouracil. (NCI Thesaurus)
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