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Dimesna
Pronunciation
Definition 1
A drug that belongs to the family of drugs called chemoprotective agents. (NCI Dictionary)
Definition 2
A synthetic derivative of dithio-ethane sulfonate with uroprotective properties. In the kidney, dimesna undergoes reduction to the free thiol compound, mesna, which reacts chemically with the urotoxic ifosfamide metabolites acrolein and 4-hydroxy-ifosfamide, resulting in their detoxification. This agent also inhibits cyclophosphamide-induced hemorrhagic cystitis. (NCI Thesaurus)
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