DNA Excision Repair Protein ERCC-1

DNA excision repair protein ERCC-1, encoded by the ERCC1 gene, is a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Its C-terminal is essential for enzymatic activity and the central region is involved in protein-protein interactions. The ERCC1 gene is involved in UV cross-link repair and nucleotide excision repair (NER). With p53 monitoring DNA damage, either XPA loads and possibly orients an incision complex, containing ERCC1 and other repair factors, to the site of DNA damage or XPA, ERCC1, and ERCC4 proteins form a ternary complex that participates in both damage recognition and incision activities. Ultraviolet light-induced DNA damage causes a transient immobilization of ERCC1/XPF to engage the complex in a single repair event. Afterwards, the complex regains mobility. (From OMIM 126380 and NCI) (NCI Thesaurus)

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