Docking Protein 1

Docking Protein 1, encoded by the human DOK1 gene, interacts with receptor tyrosine kinases and mediates particular biological responses. This 62-kD protein is associated with p120 Ras-GAP and this association is correlated with its tyrosine phosphorylation. It is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. It plays an important role in mitogenic signaling and its aberrant phosphorylation may contribute to the progression of different human diseases. It is phosphorylated by the insulin receptor kinase, resulting in the negative regulation of the insulin signaling pathway. (From LocusLink, Swiss-Prot, OMIM and NCI) (NCI Thesaurus)

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