| Health / Medical Topics |
Dolastatin 15
A depsipeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Less potent than the structurally-related compound dolastatin 10, dolastatin 15 binds weakly to tubulin and blocks microtubule assembly, thereby inhibiting mitosis. Dolastatin 15 also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers. (NCI Thesaurus)
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A family of proteins that contain both an IRS-type phosphotyrosine binding domain and a pleckstrin homology domain.
