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DOWN SYNDROME
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A congenital disorder caused by having an extra 21st chromosome; results in a flat face and short stature and mental retardation
Synonyms:
Down's syndrome; Down syndrome; mongolianism; mongolism; trisomy 21
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("Down syndrome" is a kind of...):
birth defect; congenital abnormality; congenital anomaly; congenital defect; congenital disorder (a defect that is present at birth)
trisomy (chrosomal abnormality in which there is one more than the normal number of chromosomes in a cell)
Context examples:
There is an increased risk of acute leukemias in both children and adults with Down syndrome.
(Myeloid Proliferations Related to Down Syndrome, NCI Thesaurus)
The chance of having a baby with Down syndrome increases as a woman gets older.
(Down Syndrome, NIH: National Institute of Child Health and Human Development)
Or the problem can be both physical and mental, such as Down syndrome.
(Developmental Disabilities, NIH: National Institute of Child Health and Human Development)
Patients with Down syndrome have an estimated 10 to 30-fold increased risk for leukemia; most have symptoms of Alzheimer's disease by age 40.
(Down Syndrome, NCI Thesaurus)
In particular, the incidence of acute myeloid leukemia in Down syndrome children of less than five years of age is particularly high, it is usually an acute megakaryoblastic leukemia, and is associated with GATA1 gene mutation.
(Myeloid Proliferations Related to Down Syndrome, NCI Thesaurus)
People with Down syndrome can have physical problems, as well as intellectual disabilities.
(Down Syndrome, NIH: National Institute of Child Health and Human Development)
Down syndrome is a condition in which a person is born with an extra copy of chromosome 21.
(Down Syndrome, NIH: National Institute of Child Health and Human Development)
Every person born with Down syndrome is different.
(Down Syndrome, NIH: National Institute of Child Health and Human Development)
Down syndrome cannot be cured.
(Down Syndrome, NIH: National Institute of Child Health and Human Development)
