Library / English Dictionary

EFFLUX

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

The process of flowing out

Synonyms:

effluence; efflux; outflow

Classified under:

Nouns denoting natural processes

Hypernyms ("efflux" is a kind of...):

flow (any uninterrupted stream or discharge)

Antonym:

influx (the process of flowing in)

 II. (verb) 

Sense 1

Present simple (first person singular and plural, second person singular and plural, third person plural) of the verb efflux

Credits

 Context examples: 

The tumor tissue may be passively targeted due to preferential deposition of emulsion particles while an emulsion formulation component inhibits the P-glycoprotein drug efflux pump.

(Paclitaxel Vitamin E-Based Emulsion, NCI Thesaurus)

Unlike other taxane compounds, milataxel appears to be a poor substrate for the multidrug resistance (MDR) membrane-associated P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors.

(Oral Milataxel, NCI Thesaurus)

In an animal model, inhibition of ACAT by octimibate increased HDL receptor activity and stimulated HDL-mediated cholesterol efflux from peritoneal macrophages.

(Octimibate, NCI Thesaurus)

Mechanisms involve expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, decreased topoisomerase II activity, and changes in various cellular proteins.

(Multidrug Resistance Induction, NCI Thesaurus)

Mechanisms involve decreased expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, increased topoisomerase II activity, and changes in various cellular proteins.

(Multidrug resistance inhibition, NCI Thesaurus)

Dexverapamil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms.

(Dexverapamil, NCI Thesaurus)

Dofequidar binds to the drug-binding site of the transmembrane P-glycoprotein efflux pump and is preferentially transported from the cell, thereby blocking the efflux of other therapeutic agents.

(Dofequidar, NCI Thesaurus)

This agent may also modulate multi-drug response activity through inhibition of the p-glycoprotein efflux pump.

(Amlodipine Maleate, NCI Thesaurus)

Biricodar binds directly to the plasma membrane drug-efflux pumps P-glycoprotein (P-gp) and multidrug resistance protein 1 (MRP-1) and inhibits their activities, which may result in increased intracellular accumulation and retention of cytotoxic agents.

(Biricodar Dicitrate, NCI Thesaurus)

Phenytoin sodium promotes sodium efflux from neurons located in the motor cortex, thereby stabilizing the neuron and inhibiting synaptic transmission.

(Phenytoin sodium, NCI Thesaurus)