| Health / Medical Topics |
EWS/FLI 1 Type 2
The more potent transcription activator allele of a transforming chimeric gene resulting from a t(11;22) translocation that is found frequently in Ewing's sarcoma and primitive neuroectodermal tumor (PNET). EWS-FLI1 type 2 encodes the mTOR protein, a central regulator of translation and cell proliferation that activates the mitogen-activated protein kinase (MAPK) signaling system, resulting in neoplastic transformation. Antisense oligonucleotides that target EWS-FLI1 type 2 have been used investigationally to arrest cancer cells in the G1 phase of the cell cycle. (NCI Thesaurus)
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