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EXCITABILITY
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I. (noun)
Sense 1
Meaning:
Being easily excited
Synonyms:
excitability; excitableness; volatility
Classified under:
Nouns denoting attributes of people and objects
Hypernyms ("excitability" is a kind of...):
emotionalism; emotionality (emotional nature or quality)
Hyponyms (each of the following is a kind of "excitability"):
boiling point (being highly angry or excited; ready to boil over)
Derivation:
excitable (easily excited)
Sense 2
Meaning:
Excessive sensitivity of an organ or body part
Synonyms:
excitability; irritability
Classified under:
Nouns denoting cognitive processes and contents
Hypernyms ("excitability" is a kind of...):
reactivity; responsiveness (responsive to stimulation)
Context examples:
This decreases excitability, slows the impulse conduction through the atrioventricular (AV) node and depresses depolarization.
(Moricizine Hydrochloride, NCI Thesaurus)
In addition, morphine closes N-type voltage-gated calcium channels and opens calcium-dependent inwardly rectifying potassium channels, which results in hyperpolarization of neuronal membranes and a reduction in neuronal excitability, and subsequently, analgesia and sedation.
(Morphine Sulfate Sustained-Release Tablet, NCI Thesaurus)
In addition, buprenorphine closes N-type voltage-gated calcium channels and opens calcium-dependent inwardly rectifying potassium channels, resulting in hyperpolarization, reduced neuronal excitability, analgesia and sedation.
(Buprenorphine Transdermal Matrix Patch, NCI Thesaurus)
This slows the rate and amplitude of phase 0 depolarization and thus prolongs the duration of the action potential, thereby reducing cell excitability and conduction velocity.
(Disopyramide, NCI Thesaurus)
Agents used for the treatment or prevention of cardiac arrhythmias; they may effect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers.
(Antiarrhythmic Agent, NCI Thesaurus)
The analgesic effect of fentanyl is likely due to its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability.
(Fentanyl, NCI Thesaurus)
The analgesic effect of codeine sulfate is likely due to its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability.
(Codeine Sulfate, NCI Thesaurus)
Stimulation of mu-subtype opioid receptors results in a decrease in the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline; in addition, the codeine metabolite morphine induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, resulting in hyperpolarization and reduced neuronal excitability.
(Codeine, NCI Thesaurus)
This binding leads to an opening of the chloride channels, which allows the flow of chloride ions into the neuron, hyperpolarizes the neuronal membrane, inhibits neuronal firing, and leads to a decrease in neuronal excitability.
(Estazolam, NCI Thesaurus)
Stimulation of the mu-receptor inhibits adenyl cyclase activity, induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels, and blocks the opening of N-type voltage-gated calcium channels, resulting in hyperpolarization and reduced neuronal excitability; in addition, neuronal release of neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline may decrease.
(Fentanyl Matrix Transdermal Patch, NCI Thesaurus)
