F344, Rat Strain

Definition 1

Most animals older than 2 years exhibit small local areas of nephritis; less than 25% show severe nephritis (Snell 1967). Tumors: Mammary tumors 41% in females and 23% in males, pituitary adenomas 36% in females and 24% in males, testicular interstitial cell tumors 85% in males. Other tumor types less common (Sass et al 1975). Thyroid carcinoma 22% (Lindsey et al 1968). Interstitial cell testicular tumors 65%, mononuclear cell leukemia 24%, subcutaneous fibroadenoma 9% in females. Both sexes have a 5% incidence of nodular hyperplasia of the liver. (NCI Thesaurus)

Definition 2

Derived by Curtiss and Dunning (1920) at Columbia University and disseminated to Heston (1949) and then to the NIH (1951). The Fischer 344 rat has an albino coat and genotype c. (NCI Thesaurus/CDISC)

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