| Health / Medical Topics |
FLT3/KIT Kinase Inhibitor AKN-028
An orally bioavailable protein tyrosine kinase inhibitor for FMS-related tyrosine kinase 3 (FLT3; STK1) and stem cell factor receptor (SCFR; KIT), with potential antineoplastic activity. FLT3/KIT kinase inhibitor AKN-028 binds to and inhibits both the wild-type and mutated forms of FLT3 and SCFR. This may result in an inhibition of tumor cell proliferation in cancer cell types that overexpress these receptor tyrosine kinases. (NCI Thesaurus)
YOU MAY ALSO LIKE
Human FLT3 wild-type allele is located within 13q12 and is approximately 97 kb in length. This allele, which encodes FMS-Related Tyrosine Kinase…
Single nucleotide mutations in the tyrosine kinase domain encoded by the human FLT3 gene that are associated with acute myeloid leukemia and…
Flt3 ligand is a novel hematopoietic growth factor ligand for the FLT3 tyrosine kinase receptor. This growth factor stimulates the proliferation…
A genetic abnormality that arises from duplications of the juxtamembrane portion of the gene and results in constitutive activation of the FLT3…
This gene plays a role in hematopoiesis and may function as a growth factor receptor.
Human FLT1 wild-type allele is located within 13q12 and is approximately 193 kb in length. This allele, which encodes vascular endothelial growth…
