| Health / Medical Topics |
Fomivirsen Sodium
The sodium salt form of fomivirsen, an antisense phosphorothioate oligodeoxynucleotide (ODN) with potent antiviral property. Fomivirsen is a 21-nucleotide ODN complementary to mRNA of the immediate-early region 2 of human cytomegalovirus (CMV). Hybridization of this antisense ODN to CMV mRNA prevents RNA transcription from the immediate-early region 2 gene, thereby inhibiting viral replication. In addition, this agent inhibits adsorption of CMV into host cells via a sequence-independent mechanism. Overall, fomivirsen inhibits viral propagation via inhibiting viral replication and viral uptake by host cells, hence delaying progression of CMV-associated retinitis. (NCI Thesaurus)
YOU MAY ALSO LIKE
A semisynthetic beta-lactamase-stable penicillin with antibacterial activity. Fomidacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the…
A pyrazole with competitive alcohol dehydrogenase inhibitor activity. Fomepizole prevents the metabolism of ethylene glycol and methanol by alcohol dehydrogenase, thereby inhibiting…
Folylpolyglutamate synthase, mitochondrial (587 aa, ~65 kDa) is encoded by the human FPGS gene. This protein plays a role in the conversion…
Human FOLR2 wild-type allele is located within 11q13.3-q14.1 and is approximately 5 kb in length. This allele, which encodes folate receptor beta…
This gene is involved in folic acid uptake.
Human FOLR1 wild-type allele is located within 11q13.3-q14.1 and is approximately 7 kb in length. This allele, which encodes folate receptor alpha…
