Galanin Receptor 2

Galanin Receptor 2 (GALR2) is encoded by the GALR2 gene. Galanin is an important neuromodulator, a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. Galanin Receptor 2 decreases cAMP through an inhibitory G-protein and stimulates phospholipase C and mobilizes calcium through Gq/G11. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq). (From LocusLink and NCI) (NCI Thesaurus)

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