Ganglioside

Pronunciation

Definition 1

A complex molecule that contains both lipids (fats) and carbohydrates (sugars) and is found in the plasma (outer) membrane of many kinds of cells. Several different types of gangliosides have been identified. (NCI Dictionary)

Definition 2

Sialoglycosphingolipids (synonym: gangliosides) are glycosphingolipids carrying one or more sialic residues. Sialic acid is the generic term for N-acetyl- or N-glycoloylneuraminic acid. Gangliosides are named as N-acetyl- (or N-glycoloyl-)neuraminosyl-(X)osylceramide, where (X) stands for the root name of the neutral oligosaccharide to which the sialosyl residue is attached ; found principally in nerve tissue, spleen, and thymus; GM1 accumulates in generalized gangliosidosis; GM2 accumulates in Tay-Sachs disease. (NCI Thesaurus)

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