| Health / Medical Topics |
Gastrointestinal Stromal Tumor of the Gastrointestinal Tract
A KIT-expressing and KIT-signaling-driven mesenchymal tumor involving any part of the gastrointestinal tract. It originates from the interstitial cells of Cajal. Morphologic variants include the epithelioid cell type, spindle cell type, and mixed cell type. Lesions with a diameter greater than 10cm and more than 5 mitotic figures per 50HPF tend to have a more aggressive clinical course. Until recently, surgery has been the only effective therapy for GIST. However, many patients still experience recurrence. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable GIST. (NCI Thesaurus)
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