Gemtuzumab ozogamicin

Pronunciation

Definition 1

A monoclonal antibody combined with a toxic substance that is used to treat certain types of acute myeloid leukemia in older patients and is being studied in the treatment of other types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Gemtuzumab ozogamicin is a type of antibody-drug conjugate. Also called gemtuzumab and Mylotarg. (NCI Dictionary)

Definition 2

A recombinant, humanized anti-CD33 monoclonal antibody attached to the cytotoxic antitumor antibiotic calicheamicin. In this conjugate, the antibody binds to and is internalized by tumor cells expressing CD33 antigen (a sialic acid-dependent glycoprotein commonly found on the surface of leukemic blasts), thereby delivering the attached calicheamicin to CD33-expressing tumor cells. Calicheamicin binds to the minor groove of DNA, causing double strand DNA breaks and resulting in inhibition of DNA synthesis. (NCI Thesaurus)

YOU MAY ALSO LIKE

Gemtuzumab

A monoclonal antibody combined with a toxic substance that is used to treat certain types of acute myeloid leukemia in older patients…

GEMOX

A chemotherapy combination used to treat pancreatic cancer and some other types of cancer. It includes the drugs gemcitabine hydrochloride and…

Gemistocytic Neoplastic Astrocyte

A pathologic astrocyte in which the cell body swells and contains glial filaments and an eccentric nucleus; seen particularly in demyelinating and…

Gemistocytic Astrocytoma

A rare variant of diffuse astrocytoma. It is characterized by the presence of a conspicuous, though variable, fraction of gemistocytic neoplastic…

Geminin

Geminin (209 aa, ~24 kDa) is encoded by the human GMNN gene. This protein is involved in the modulation of DNA…

Gemifloxacin Mesylate

The mesylate salt form of gemifloxacin, a synthetic broad-spectrum fluoroquinolone with antibacterial activity. Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase…