Library / English Dictionary

GENE MUTATION

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

(genetics) a mutation due to an intramolecular reorganization of a gene

Synonyms:

gene mutation; point mutation

Classified under:

Nouns denoting natural events

Hypernyms ("gene mutation" is a kind of...):

chromosomal mutation; genetic mutation; mutation ((genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism)

Domain category:

genetic science; genetics (the branch of biology that studies heredity and variation in organisms)

Credits

 Context examples: 

You can inherit a gene mutation from one or both parents.

(Genetic Disorders, NIH: National Library of Medicine)

Cancer gene mutations include both activation of oncogenes and inactivation of tumor suppressor genes.

(Cancer Gene Mutation, NCI Thesaurus)

People who have the natural gene mutation appear to have an advantage when it comes to diet.

(Gene mutation points to new way to fight diabetes, obesity, heart disease, National Institutes of Health)

It has been associated with KRAS and Tp53 gene mutations.

(Pancreatic Intraductal Papillary-Mucinous Carcinoma, NCI Thesaurus)

The mice had been engineered with a human gene mutation previously linked to stuttering.

(Study in mice identifies type of brain cell involved in stuttering, National Institutes of Health)

A term referring to acute myeloid leukemias associated with gene mutations most often of the FLT3, NPM1, and CEBPA genes.

(Acute Myeloid Leukemia with Gene Mutations, NCI Thesaurus)

For example, some people who have a BRCA1 or BRCA2 gene mutation will develop cancer during their lifetime, but others will not.

(Penetrance, NCI Dictionary)

The likelihood that an individual with a negative test result is truly unaffected and/or does not have the particular gene mutation in question.

(Negative Predictive Value of Diagnostic Test, NCI Dictionary)

This group of disorders also includes the entity transient abnormal myelopoiesis which occurs in neonates and is associated with GATA1 gene mutation.

(Myeloid Proliferations Related to Down Syndrome, NCI Thesaurus)

This BRAF gene mutation may be found in some types of cancer, including melanoma and colorectal cancer.

(BRAF (V600E) mutation, NCI Dictionary)