| Health / Medical Topics |
General Transcription Factor 3B 90-kD Subunit
Encoded by human BRF1 Gene (TFIIB Family), alternative isoforms 1 (677-aa, 74-kD), 2 (134-aa, altered N- and C-termini), 3 (473-aa, shorter N-terminus), and 4 (242-aa) of General Transcription Factor 3B 90-kD Subunit function at different promoters on tRNA, 5S rRNA, and other small RNA genes. Related to GTF2B (N-terminus), GTF3B contains a highly charged region and HMG2-related region. Essential for transcription initiation, GTF3B (C-terminus) binds TBP (collectively, TFIIIB) as one of three RNA polymerase III transcription factor subunits. Following GTF3A or GTF3C recognition of promoter elements, GTF3B and RNA polymerase III bind sequentially. (NCI Thesaurus)
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